221 North Main Street
Ste. Geneviève, MO 63670

Call us at 573-880-7500
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Originally built in 1882, as the Meyer Hotel, the Main Street Inn B&B has long been one of Missouri’s finest bed and breakfast establishments. After recently undergoing an extensive year-long renovation, the new owners and innkeeper are thrilled to re-open the Main Street Inn B&B and welcome our guests to what we hope will be a truly wonderful experience.

If you are looking for a relaxing and peaceful getaway, the Main Street Inn B&B is the perfect destination.