All Hotels and Inns in Sainte Genevieve

Audubon’s Hotel At 9 North Main Street in the heart of historic downtown Ste. Genevieve, Audubon’s combines seven beautifully renovated boutique hotel rooms with one of the town’s favorite restaurants and bars. Housed in a building that has been part of the community since the early 1900s, it’s an ideal place to settle in for a weekend of history, good food, and a little small-town revelry. The location is hard to beat. Historic homes, museums, galleries, shops, and some of Ste. Genevieve’s best dining and entertainment are just a short walk away. Better yet, Audubon’s has a restaurant downstairs serving scratch-made French, Cajun, German, and Italian dishes. You can spend the day exploring town, enjoy a proper dinner, have a nightcap, and make it back to your room without ever looking for your car keys. A Storied Past Audubon’s has been a part of downtown Ste. Genevieve for more than a century, and its history is nearly as colorful as the town itself. The story begins in 1901, when Charles Petrequin purchased the property for a little over $2,000. By 1903, it was home to the Palace Bar, a popular local watering hole whose name still inspires a little nostalgia Read more…

Dr. Hertich House Built in 1850 as both residence and medical clinic for Dr. Charles Hertich, one of Ste. Genevieve’s first full-time physicians, this French Chateau-style building with distinctive mansard roof now serves as a heritage hotel blending historic elegance with modern luxury. Located at 99 North Main Street in the heart of downtown, Dr. Hertich House offers four three-room suites with king beds, gas fireplaces, and two-person jacuzzi tubs—plus Der Bierkeller, a unique basement apartment nestled within original 1801 stone foundation walls. Under new ownership by Dr. Sandra Hoffmann (herself a practicing physician at Ste. Genevieve County Memorial Hospital), the property continues the medical legacy while delivering what guests call “the ultimate in comfort.” As one anniversary couple raved: “My wife and I stayed in the Memories Suite and it was perfect. Extremely comfortable king bed, easy-to-use gas fireplace at the foot of the bed, and an awesome two-person jetted tub with complimentary bath salts. We had the stuffed french toast delivered to our suite the following morning—5 star service!” Practical Information Location: 99 North Main Street, downtown Ste. Genevieve, Missouri 63670 Building History: Built 1850; served as Dr. Charles Hertich’s residence and medical clinic; French Chateau style with Read more…

Main Street Inn Bed & Breakfast At 221 North Main Street in historic downtown Sainte Geneviève, the Main Street Inn is a beautifully restored 1882 Victorian hotel with ten distinctive guest rooms, a remarkable collection of contemporary art, and a front porch that practically insists you sit down and stay awhile. Owners Patrick Fahey and Susan O’Donnell spent a full year renovating the former Meyer Hotel, preserving its original architecture while bringing the accommodations comfortably into the 21st century. Today, the inn is equal parts historic landmark, art gallery, and welcoming home away from home. Guests enjoy a freshly prepared breakfast each morning, complimentary wine and cheese in the evening, and the sort of personal hospitality that’s becoming increasingly difficult to find. And then there’s the art. Original works by Shepard Fairey, Bryan Haynes, and other celebrated artists hang throughout the property, making a trip to your room feel a little like wandering through a private collection. It’s an unexpected pleasure in a town already full of surprises. A Victorian Landmark, Beautifully Restored Originally built in 1882 as the Meyer Hotel, the Main Street Inn has been welcoming travelers to Sainte Geneviève for well over a century. Its three-story brick Read more…

Southern Hotel  235-Year-Old Landmark, Oldest Continuously Operating Hotel West of the Mississippi At 146 South Third Street in downtown Ste. Genevieve, the Southern Hotel stands as “oldest longest operating hotel or lodging establishment in the United States West of the Mississippi”—built 1790, serving patrons since 1805 for 235+ years. This Federal-style bed & breakfast features 9 themed guest rooms (each with private bath, individual climate control, period antiques), innkeepers Mike and Cathy’s renowned hospitality including “Cathy’s wholesome and tasty breakfast” and Mike’s complimentary “Wine, Cheese and History” evening sessions, plus secret garden with evening twinkle lights. Location delivers walkability: 0.1 miles to Felix Vallé House State Historic Site, 0.2 miles to Bolduc House Museum, 0.1 miles to Ste. Genevieve Catholic Church, plus restaurants and shopping within blocks. Featured in House Beautiful’s “50 Most Beautiful Small Towns in America” (#25, pictured: Southern Hotel’s welcoming porch rockers) and best-selling author Richard Paul Evans’ novel “A Step of Faith.” Guest testimonial: “I’ve stayed at b+b’s from Alaska to Arkansas, and this one beats them all! Caring devotion to guest’s needs, a lovely bed, charmingly appointed room featuring a claw-foot bathtub, and history galore on the walls and in display cabinets.” Phone: (573) 883-3493. Read more…

Inn St. Gemme Beauvais At 78 North Main Street in the heart of Sainte Geneviève’s historic district stands Inn St. Gemme Beauvais—Missouri’s oldest continuously operating bed and breakfast, a three-story Federal-style mansion built circa 1848 by Felix Rozier, son of Ferdinand Rozier who partnered with John James Audubon in Ste. Genevieve from 1811-1812 before Audubon devoted himself fully to ornithology and creating The Birds of America. The inn carries the “St. Gemme Beauvais” name honoring Jean Baptiste St. Gemme dit Beauvais Jr., who supported George Rogers Clark’s Revolutionary War Illinois campaign and built the nearby Beauvais-Amoureux House in 1792—connecting guests to layered historical pedigree spanning French colonial settlement, American Federal architecture, and Rozier-Vallé family lead mining prosperity. Today’s Inn St. Gemme Beauvais offers eight themed guest rooms plus private Carriage House, each with period antiques, private bathrooms, king or queen beds, cable TV, and individual climate control, plus full plated breakfasts featuring local farm-fresh ingredients, second-floor kitchenette, beautiful gardens, off-street parking, and location placing guests within walking distance of every historic site, restaurant, shop, and cultural attraction. As one recent guest praised: “Been home for several hours and still feel relaxed from our stay. The Inn is stunning…Super clean, quiet, Read more…